When using Spectrasonics instruments within a DAW, the latest versions require a 64-bit DAW.

Starting with MacOS 10.15 Catalina, all applications will only work in 64-bit.

If you're using MacOS 10.14 Mojave or earlier, we suggest that you run it as a 64-bit application. This will allow you to access any RAM you have in excess of 4GB. 32-bit hosts can only access a little more than 3GB of Virtual Memory.

Most current DAWs are 64-bit compatible. To run your host in 64 bit mode on an older Mac operating system, please locate the icon in your applications folder for your host. Right click (or control + click) the icon and then Get Info. In the window that opens, please uncheck "Open in 32-bit mode"

Reopen your host and it will scan for 64 bit instruments.

Although it is not recommended, if you must use a 32bit DAW you will need to install an older version of your instrument:

Omnisphere: Install Software Version 2.4.2c, Patch Library Version 2.4.0d, and Soundsource Library Version 2.0.1c. from here: Omnisphere Legacy Updates

Next, please delete the following files: 
 
PC
 
C:/ProgramData/Spectrasonics/STEAM/Omnisphere/Settings Library/Patches/Factory/Hardware Library.db  
 
C:/ProgramData/Spectrasonics/STEAM/Omnisphere/Settings Library/Presets/Factory/Hardware Profiles.db  

Note: ProgramData is normally a hidden folder. To "Show Hidden Files" go to Start Menu/Control Panel/Appearance And Personalization/Folder Options/View tab. Select the "Show Hidden Files and Folders" option and hit "Apply”.
 
MAC 
 
Macintosh HD/ Users/ / Library/ Application Support/ Spectrasonics/ STEAM/ Omnisphere/ Settings Library/ Patches /Factory/ Hardware Library.db  
 
Macintosh HD/ Users/ / Library/ Application Support/ Spectrasonics/ STEAM/ Omnisphere/ Settings Library/ Presets /Factory/ Hardware Profiles.db  
 
Note: To access this hidden Library click Go from the main apple menu at the top of the screen. 
When the go menu is visible hold the Option key - Library will appear and you can select Library at that point.

Trilian: Install Software Version 1.4.5d, Patch Library Version 1.4.9d from here: Trilian Legacy Updates

Next, please delete the following file: 
 
PC
 
C:/ProgramData/Spectrasonics/STEAM/Trilian/Settings Library/Patches/Factory/ Trilian Creative.db 

Note: ProgramData is normally a hidden folder. To "Show Hidden Files" go to Start Menu/Control Panel/Appearance And Personalization/Folder Options/View tab. Select the "Show Hidden Files and Folders" option and hit "Apply”.
 
MAC 
 
Macintosh HD/ Users/ / Library/ Application Support/ Spectrasonics/ STEAM/ Trilian/ Settings Library/ Patches /Factory/ Trilian Creative.db

Note: To access this hidden Library click Go from the main apple menu at the top of the screen. 
When the go menu is visible hold the Option key - Library will appear and you can select Library at that point.

Stylus RMX: Install Software Version 1.9.9c2 (and earlier) from here: Stylus RMX Legacy Updates

Keyscape: Only compatible in 64-bit hosts

NOTE: Most current hosts, like Logic Pro X, Ableton Live 11, and ProTools 2021 only support 64bit plugins.